Safe and Quality Medicines

Safe & Quality Medicines Overview

The research provides data and evidence on population based estimates and risk prediction of adverse drug events (ADEs) in the primary and secondary care settings. It includes the ADAPT study which is a prospective study examining the prevalence of ADRs in hospital admissions following an adverse drug event. It also includes research using large epidemiological studies of high risk medicines and associated outcomes.


A mixed methods approach to the evaluation of the ‘Know Check Ask’ medication safety campaign amongst Healthcare professionals and patients/care-givers.

The aim of this research was to identify the barriers and enablers to implementation of the ‘Know Check Ask’ campaign and ’My Medicines’ list and the impact in people taking medicines, care-givers and healthcare professionals. A final report was produced which collated and summarised all the research findings. Supplementary material referred to in this report can be accessed here:

Additional file 1: O’Donovan B, Kirke C, Pate M, et al. (2022). ‘Everyone should know what they’re on’: a qualitative study of attitudes towards and use of patient held lists of medicines among patients, carers and healthcare professionals in primary and secondary care settings in Ireland. BMJ Open;12:e064484.

Additional file 2: Consolidated Framework for Implementation Research and Theoretical Domains Framework

Additional file 3: Interview topic guides (WP 1)

Additional file 4: Six suggestions to improve medication safety campaign (WP 1)

Additional file 5: Surveys (WP 2)

Additional file 6: Study documents – information leaflet, email invitation (WP 2)

Additional file 7: Thematic analysis of free text comments

Additional file 8: Workshop documents – information leaflet, invitation email (WP 3)

Additional file 9: Workshop themes 1-9

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ADAPT study

Abstract from BMJ open paper Older people experience greater morbidity with a corresponding increase in medication use resulting in a potentially higher risk of adverse drug reactions (ADRs). The aim of this study is to determine the prevalence and characteristics of ADR-related hospital admissions among older patients (≥65 years) and their associated health and cost outcomes. Methods and analysis: The proposed study includes a cross-sectional study of ADR prevalence in all patients aged ≥65 years admitted acutely to a large tertiary referral hospital in Ireland over a 9-month period (2016–2017) and a prospective cohort study of patient-reported health outcomes and costs associated with ADR-related hospital admissions. All acute medical admissions will be screened for a suspected ADR-related hospital admission. A number of validated algorithms will be applied to assess the type, causative medications, preventability and severity of each ADR. Patients who provided consent were followed up 3 months post-discharge to establish patient reported health outcomes (health service use, health related quality of life, adherence) and costs associated with ADR-related hospital admissions. A random sample of patients admitted to hospital without a suspected ADR were also be invited to take part in the study as a control group.  learn more